01 - Whisk buttermilk with salt, garlic powder, onion powder, cayenne pepper, and black pepper in a large bowl until fully combined. Submerge chicken pieces in marinade, ensuring complete coverage. Cover bowl and refrigerate for minimum 2 hours, preferably overnight for optimal flavor penetration.
02 - Combine flour, paprika, salt, black pepper, cayenne pepper, and baking powder in a separate large bowl. Whisk thoroughly to distribute spices evenly throughout the flour mixture.
03 - Remove chicken from marinade, allowing excess liquid to drip off. Press each piece firmly into flour mixture, coating completely and creating a thick, even layer. Transfer coated pieces to wire rack and rest for 10 minutes to allow coating to set.
04 - Pour vegetable oil into deep fryer or heavy-bottomed pot, ensuring sufficient depth to fully submerge chicken. Heat oil to 350°F, monitoring temperature with kitchen thermometer for accuracy.
05 - Carefully lower chicken pieces into hot oil in small batches to maintain oil temperature. Fry for 12 to 15 minutes, turning occasionally for even cooking, until coating achieves deep golden brown color and internal temperature reaches 165°F.
06 - Transfer fried chicken to wire rack or paper towels to drain excess oil. Let rest for 5 minutes before serving to allow juices to redistribute throughout meat.